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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription... more
Product information "Anti-PPARA"
Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid ß-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-?B, causing inhibition of its signaling pathway or reducing the activated levels of NF-?B and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase. Protein function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. [The UniProt Consortium]
Keywords: | Anti-Ppara, Anti-Nr1c1, Anti-PPAR-alpha, Anti-Nuclear receptor subfamily 1 group C member 1, Anti-Peroxisome proliferator-activated receptor alpha, PPARA Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-70253 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PPARa |
Database Information
KEGG ID : | K07294 | Matching products |
UniProt ID : | P23204 | Matching products |
Gene ID | GeneID 19013 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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