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Track device being used
![Anti-PLK4](https://www.biomol.com/media/image/b5/cf/3f/ATA-HPA035026-25_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ATA-HPA035026.25 | 25 µl | - |
7 - 10 business days* |
335.00€
|
|||
ATA-HPA035026.100 | 100 µl | - |
7 - 10 business days* |
446.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Serine/threonine-protein kinase that plays a central role in centriole... more
Product information "Anti-PLK4"
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 48% and to rat: 51%
Keywords: | Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18, Anti-Serine/threonine-protein kinase Sak, Anti-Serine/threonine-protein kinase PLK4 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | HPA035026 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QWGNQETSNS GRGRVIQDAE ERPHSRYLRR AYSSDRSGTS NSQSQAKTYT MERCHSAEML SVSKRSGGGE NEERYSPTDN NANIFNFFKE KTSSSSGSFE (ATA-APrEST80474) |
Database Information
KEGG ID : | K08863 | Matching products |
UniProt ID : | O00444 | Matching products |
Gene ID | GeneID 10733 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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