Anti-PLK4

Anti-PLK4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ATA-HPA035026.25 25 µl -

7 - 10 business days*

335.00€
ATA-HPA035026.100 100 µl -

7 - 10 business days*

446.00€
 
Protein function: Serine/threonine-protein kinase that plays a central role in centriole... more
Product information "Anti-PLK4"
Protein function: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 48% and to rat: 51%
Keywords: Anti-SAK, Anti-PLK4, Anti-PLK-4, Anti-Polo-like kinase 4, Anti-Serine/threonine-protein kinase 18, Anti-Serine/threonine-protein kinase Sak, Anti-Serine/threonine-protein kinase PLK4
Supplier: Atlas Antibodies
Supplier-Nr: HPA035026

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: QWGNQETSNS GRGRVIQDAE ERPHSRYLRR AYSSDRSGTS NSQSQAKTYT MERCHSAEML SVSKRSGGGE NEERYSPTDN NANIFNFFKE KTSSSSGSFE (ATA-APrEST80474)

Database Information

KEGG ID : K08863 | Matching products
UniProt ID : O00444 | Matching products
Gene ID : GeneID 10733 | Matching products
Protein Atlas Nr. : ENSG00000142731

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-PLK4"
Write a review
or to review a product.
Viewed