Anti-PINK1 (Clone: ABM5D85)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABE-10-1061-25	25 µg		-		3 - 11 business days*		149.00€

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Protein function: Protects against mitochondrial dysfunction during cellular stress by... more

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Product information "Anti-PINK1 (Clone: ABM5D85)"

Protein function: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10. [The UniProt Consortium]

Keywords:	Anti-BRPK, Anti-PINK1, Anti-PTEN-induced putative kinase protein 1, Anti-Serine/threonine-protein kinase PINK1, mitochondrial, Monoclonal Antibody to PINK1 (Clone: ABM5D85)
Supplier:	Abeomics
Supplier-Nr:	10-1061-25

Properties

Application:	WB
Antibody Type:	Monoclonal
Clone:	ABM5D85
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	A partial length recombinant PINK1 protein (a.a 93-301) was used as the immunogen for this antibody.
Format:	Purified