Anti-phospho-ADAM17 / TACE (Thr735)

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ARG66278.100	100 µl		-	-	6 - 14 business days*		30 %	624.00€ 436.80€

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Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form... more

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Product information "Anti-phospho-ADAM17 / TACE (Thr735)"

Protein function: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF- receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). [The UniProt Consortium]

Keywords:	Anti-phospho-CSVP, Anti-phospho-ADAM17, Anti-phospho-CD156b, Anti-phospho-ADAM 17, Anti-phospho-TNF-alpha convertase, Anti-phospho-Snake venom-like protease, Anti-phospho-TNF-alpha-converting enzyme
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG66278

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat)
Immunogen:	KLH-conjugated phospho-specific peptide around Thr735 (PQT(p)PG) of Human ADAM17
Format:	Affinity Purified