Anti-PGC-1 (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00029-T	10 µl (2500 ng)		-		2 - 8 business days*		178.00€
IHC-00029	100 µl (25 µg)		-		2 - 8 business days*		668.00€

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Protein function: Transcriptional coactivator for steroid receptors and nuclear receptors.... more

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Product information "Anti-PGC-1 (IHC)"

Protein function: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. [The UniProt Consortium]

Keywords:	Anti-LEM6, Anti-PPARGC1A, Anti-PGC-1-alpha, Anti-PPARGC-1-alpha, Anti-Ligand effect modulator 6, Anti-PPAR-gamma coactivator 1-alpha, Anti-Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00029

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	synthetic peptide. The epitope recognized by IHC-00029 maps to a region between residue 250 and 300 of human peroxisome proliferative activated receptor, gamma, coactivator 1, alpha using the numbering given in SwissProt entry Q9UBK2 (GeneID 10891).
Format:	Antigen Affinity Purified