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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone... more
Product information "Anti-PEX19"
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. Protein function: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. [The UniProt Consortium]
Keywords: | Anti-HK33, Anti-PEX19, Anti-Peroxin-19, Anti-33 kDa housekeeping protein, Anti-Peroxisomal farnesylated protein, Anti-Peroxisomal biogenesis factor 19, PEX19 Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-60982 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant protein of human PEX19 |
Database Information
KEGG ID : | K13337 | Matching products |
UniProt ID : | P40855 | Matching products |
Gene ID : | GeneID 5824 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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