Anti-PD-L1 / B7-H1 / CD274, clone PDL1/2746

Anti-PD-L1 / B7-H1 / CD274, clone PDL1/2746
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3955SAF-100UG 100 µg - -

3 - 10 business days*

781.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86)... more
Product information "Anti-PD-L1 / B7-H1 / CD274, clone PDL1/2746"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T-cell proliferation, cytokine production, differentiation of effector T-cells and the induction of BCLX, a promoter of T-cell survival. recruitment of CTLA4 by B7-1 or B7-2, on the other hand, may inhibit proliferation and interleukin-2 (IL-2) production. PD-L1 is 290-amino acid type I transmembrane protein, which is 20% and 15% identical to B7-1 and B7-2, respectively, has immunoglobulin V-like and C-like domains and a 30-amino acid cytoplasmic tail. PD-L1 does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of PD-L1 co-stimulation. PD-L2 protein contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. Constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases. Protein function: Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). [The UniProt Consortium]
Keywords: Anti-B7H1, Anti-PD-L1, Anti-B7-H1, Anti-CD274, Anti-B7 homolog 1, Anti-PDCD1 ligand 1, Anti-Programmed death ligand 1, Anti-Programmed cell death 1 ligand 1, PD-L1 Antibody / B7-H1 / CD274
Supplier: NSJ Bioreagents
Supplier-Nr: V3955SAF

Properties

Application: IHC (paraffin), WB, FC, IF/ICC
Antibody Type: Monoclonal
Clone: PDL1/2746
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: A portion of amino acids 39-191 from the human protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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