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Track device being used
![Anti-PCNA (PE), clone PC10](https://www.biomol.com/media/image/10/cb/c8/ARG57572-50_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG57572.50 | 50 tests | - | - |
6 - 14 business days* |
520.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of... more
Product information "Anti-PCNA (PE), clone PC10"
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [The UniProt Consortium]
Keywords: | Anti-PCNA, Anti-Pcna, Anti-Cyclin, Anti-Proliferating cell nuclear antigen |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG57572 |
Properties
Application: | FC, ICC, IF, IHC (frozen), IHC (paraffin), WB |
Antibody Type: | Monoclonal |
Clone: | PC10 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat, chicken, Drosophila , primates |
Immunogen: | Recombinant Rat PCNA |
Format: | Purified |
Database Information
KEGG ID : | K04802 | Matching products |
UniProt ID : | P04961 | Matching products |
Gene ID | GeneID 25737 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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