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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay32209-100 | 100 µl | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Paxillin is a focal adhesion adapter protein that facilitates the assembly of multiprotein... more
Product information "Anti-Paxillinalpha/beta/gamma (N-Term) Rabbit Monoclonal Antibody (Clone RM256)"
Paxillin is a focal adhesion adapter protein that facilitates the assembly of multiprotein complexes that mediate signal transduction between the extracellular matrix and actin cytoskeleton. It contains four LIM domains in the C-terminal region that target paxillin to focal adhesions and an N-terminal region with five LD motifs that serve as docking sites for a variety of proteins, including vinculin, focal adhesion kinase (FAK), and Src, that facilitate intracellular signal transduction. Alternative splicing of PXN generates three isoforms, alpha, beta, and gamma, that contain a variable N-terminus, as well as a fourth isoform, delta, that lacks the N-terminal region. Paxillin is expressed in most tissues and predominately localizes to focal adhesions on the cell membrane. Upon cytokine or growth factor stimulation or cell adhesion, paxillin is phosphorylated by a variety of kinases, including FAK and ERK, providing a scaffold for signaling proteins that are involved in the formation and regulation of focal adhesions, which mediate cell migration. It is also expressed in the cytoplasm and nucleus where it regulates gene transcription. Tumor paxillin levels are increased in patients with glioblastoma multiforme (GBM) and associated with poor survival. Cayman's Paxillinalpha/beta/gamma (N-Term) Rabbit Monoclonal Antibody (Clone RM256) can be used for immunocytochemistry (ICC) and Western blot (WB) applications.Immunogen: Peptide from the N-terminal region of human paxillinalpha/beta/gamma. Clone Designation: RM256. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ICC and WB.
Keywords: | Anti-PXN, Anti-Paxillin |
Supplier: | Cayman Chemical |
Supplier-Nr: | 32209 |
Properties
Application: | ICC, WB |
Antibody Type: | Monoclonal |
Clone: | RM256 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | vertebrates |
Immunogen: | Peptide from the N-terminal region of human paxillin?/?/? |
Format: | Purified |
Database Information
KEGG ID : | K05760 | Matching products |
UniProt ID : | P49023 | Matching products |
Gene ID : | GeneID 5829 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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