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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG44563.100 | 100 µl | - | - |
6 - 14 business days* |
624.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Catalyzes the citrullination/deimination of arginine residues of proteins such... more
Product information "Anti-PADI4 / PAD4"
Protein function: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. [The UniProt Consortium]
Keywords: | Anti-PAD4, Anti-PADI4, Anti-HL-60 PAD, Anti-HL-60 PAD, Anti-Peptidylarginine deiminase IV, Anti-Peptidylarginine deiminase IV, Anti-Protein-arginine deiminase type-4, Anti-Protein-arginine deiminase type-4, Anti-Protein-arginine deiminase type IV, Anti-Pr |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG44563 |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant human PADI4 / PAD4 |
MW: | 74 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K24669 | Matching products |
UniProt ID : | Q9UM07 | Matching products |
Gene ID | GeneID 23569 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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