Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
![Anti-PAD2](https://www.biomol.com/media/image/2e/02/08/Cay33887-500_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay33887-500 | 500 µg | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues to citrulline... more
Product information "Anti-PAD2"
Protein arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues to citrulline within cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function. It is composed of an alpha/beta propeller domain, an IgG1 domain that contains calcium binding sites, and an IgG2 domain. PAD2 changes conformation upon calcium binding to the IgG1 domain, which activates PAD2 and allows its substrates to bind. It is ubiquitously expressed with high expression in the brain, spleen, muscle, and spinal cord and is localized primarily to the cytoplasm but can translocate to the nucleus in response to calcium signaling. PAD2 citrullinates non-histone proteins, such as glial fibrillary acid protein (GFAP), myelin basic protein (MBP), and retinoic acid receptor-related orphan receptor gamma (RORgamma), as well as histone H3 at arginine 26 (H3R26), to regulate diverse processes ranging from myelination to immune function. PADI2, the gene encoding PAD2, is highly expressed in tumors from patients with breast cancer and associated with poor prognosis. It is also overexpressed in a variety of other cancers, including castration-resistant prostate, ovarian, and lung cancers, among others. PAD2 has been found in the synovial fluid of patients with rheumatoid arthritis (RA), and anti-PAD2 antibodies are associated with less severe RA than patients with autoantibodies to PAD4. Cayman's PAD2 Polyclonal Antibody can be used for ELISA and Western blot (WB) applications. The antibody recognizes PAD2 at approximately 77 kDa from human samples.Synonyms: PADI2, PAD-H19, Petidylarginine Deiminase 2, Protein Arginine Deiminase 2. Immunogen: Recombinant human PAD2. MW: ~77 kDa. Formulation: (Request formulation change), 500 µg of protein A-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, containing 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA, WB. Cross Reactivity: (+) PAD2. UniProt Accession #: Q9Y2J8.
Keywords: | Anti-PADI2, Anti-PAD-H19, Anti-PAD-H19, Anti-KIAA0994, Anti-Peptidylarginine deiminase II, Anti-Peptidylarginine deiminase II, Anti-Protein-arginine deiminase type-2, Anti-Protein-arginine deiminase type-2, Anti-Protein-arginine deiminase type II, Anti-Pr |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33887 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant human PAD2 |
Format: | Solution |
Database Information
KEGG ID : | K01481 | Matching products |
UniProt ID : | Q9Y2J8 | Matching products |
Gene ID | GeneID 11240 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed