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![Anti-p65](https://www.biomol.com/media/image/a0/c8/c5/ABE-11-6002-100_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-11-6002-100 | 100 µg | - |
3 - 11 business days* |
387.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
P65 is a subunit of the NF-KappaB, a second messenger, which activates the transcription of a... more
Product information "Anti-p65"
P65 is a subunit of the NF-KappaB, a second messenger, which activates the transcription of a number of genes in multiple tissues. It is a ubiquitously expressed protein that can bind to the kB site alone. In addition, p65 is shown to be the subunit responsible for providing transcriptional activity of the NF-kB (p65-p50) heterodimeric complex. The inhibitory effect of I-KappaB upon NF-KappaB in the cytoplasm is exerted primarily through the interaction with P65. It shows a weak DNA binding site, which could contribute directly to DNA binding in the NF-KappaB complex. Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA- NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin- mediated activation of IL-8 expression. [The UniProt Consortium]
Keywords: | Anti-RELA, Anti-NFKB3, Anti-Transcription factor p65, Anti-Nuclear factor NF-kappa-B p65 subunit, Anti-Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Polyclonal Antibody to p65 |
Supplier: | Abeomics |
Supplier-Nr: | 11-6002 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse) |
Immunogen: | A partial length recombinant p65 protein (amino acids 1-200) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K04735 | Matching products |
UniProt ID : | Q04206 | Matching products |
Gene ID | GeneID 5970 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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