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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG56928.50 | 50 µl | - | - |
6 - 14 business days* |
30 %
|
488.00€
341.60€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome... more
Product information "Anti-Nucleophosmin, clone 5E3"
Protein function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). [The UniProt Consortium]
Keywords: | Anti-NPM, Anti-NPM1, Anti-Numatrin, Anti-Nucleophosmin, Anti-Nucleolar protein NO38, Anti-Nucleolar phosphoprotein B23 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG56928 |
Properties
Application: | WB, IHC (paraffin), ICC, IF, FC |
Antibody Type: | Monoclonal |
Clone: | 5E3 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant fragment around aa. 81-294 of Human Nucleophosmin |
Format: | Purified |
Database Information
KEGG ID : | K11276 | Matching products |
UniProt ID : | P06748 | Matching products |
Gene ID : | GeneID 4869 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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