Anti-NT-proBNP (Capture/Detector)

Brain-type Natriuretic Peptide (BNP) is a nonglycosylated peptide that is produced predominantly by ventricular myocytes and belongs to the natriuretic peptide family. Proteolytic cleavage of the 12 kDa BNP precursor gives rise to N-terminal proBNP (NT-proBNP) and mature BNP. Plasma NT-proBNP is a marker for congestive heart failure,while mature BNP (aa 103 - 134) promotes vasodilation and fluid and sodium excretion. Protein function: [Brain natriuretic peptide 45]: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:8182124). May also function as a paracrine antifibrotic factor in the heart (PubMed:10737768). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:8182124). Likely involved in regulating the extracellular fluid volume and maintaining the fluid- electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis. [The UniProt Consortium]