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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay14114-1 | 1 each | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor... more
Product information "Anti-Nrf2 (N-Term)"
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor encoded by NFE2L2 in humans that regulates the cellular antioxidant response. It is a 605-amino acid protein comprised of seven highly conserved Nrf2-ECH (Neh) homology domains. Nrf2 contains a large central domain that recruits transcriptional co-activators, mediates heterodimerization with the transcription factor Maf, and can be phosphorylated by GSK3 or the ubiquitin ligase adapter protein beta-TrCP. The Nrf2 central domain is flanked by an N-terminal Neh2 domain that binds the negative regulator Kelch-like ECH-associated protein 1 (Keap1, Cay-32035) and a C-terminal Neh3 domain that is required for transactivation. Nrf2 is ubiquitously expressed and, under homeostatic conditions, associates with Keap1 in the cytoplasm, preventing Nrf2 nuclear translocation and promoting its ubiquitination and proteasomal degradation. In the presence of xenobiotic electrophiles or oxidants, Keap1 releases Nrf2 which translocates to the nucleus, dimerizes with Maf, and induces the expression of a variety of cytoprotective genes that have antioxidant, anti-inflammatory, and metabolic functions. Nrf2 siRNA knockdown increases DNA-crosslinking and apoptosis induced by cisplatin (Cay-13119) in A549 cancer cells, indicating that Nrf2 contributes to chemoresistance. Tumor Nrf2 levels are increased in patients with non-small cell lung cancer (NSCLC) and this increase is associated with poor overall survival. Cayman's Nrf2 (N-Term) Polyclonal Antibody can be used for flow cytometry (FC), immunocytochemistry (ICC), and Western blot (WB) applications. The antibody recognizes native and polyubiquitinated Nrf2 at 67 and 90 kDa, respectively, from human, mouse, and rat samples.Synonyms: GABPA, HEBP1, NF-E2-related factor 2, Nuclear Factor Erythroid 2-related factor 2. Immunogen: Peptide from the N-terminal region of human Nrf2 protein. MW: 67 and 90 kDa for native and polyubiquitinated Nrf2, respectively. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: FC, ICC, IF, WB. UniProt Accession #: Q16236.
Keywords: | Anti-HEBP1, Anti-HEBP1, Anti-Nrf-2 {ECO:0000303|PubMed:11256947}, Anti-Nrf-2 {ECO:0000303|PubMed:11256947}, Anti-NFE2-related factor 2 {ECO:0000303|PubMed:11035812}, Anti-NFE2-related factor 2 {ECO:0000303|PubMed:11035812}, Anti-NF-E2-related factor 2 {EC |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14114 |
Properties
Application: | FC, ICC, IF, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Peptide from the N-terminal region of human Nrf2 protein |
Format: | Solid |
Database Information
KEGG ID : | K05638 | Matching products |
UniProt ID : | Q16236 | Matching products |
Gene ID : | GeneID 4780 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H319 |
P Phrases: | P264, P270, P280, P321, P330, P301+P310, P302+P352, P305+P351+P338, P332+P313, P337+P313, P362+P364, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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