Anti-NRCAM

Anti-NRCAM
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ELK-ES11299.50 50 µl - -

10 - 14 business days*

169.00€
ELK-ES11299.100 100 µl - -

10 - 14 business days*

283.00€
 
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a... more
Product information "Anti-NRCAM"
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], Protein function: Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes, not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cell membrane , Single-pass type I membrane protein . Cell projection, axon . Secreted . Detected at nodes of Ranvier. .
Keywords: Anti-NRCAM, Anti-hBravo, Anti-Nr-CAM, Anti-KIAA0343, Anti-Ng-CAM-related, Anti-Neuronal surface protein Bravo, Anti-Neuronal cell adhesion molecule, Anti-NgCAM-related cell adhesion molecule, NRCAM rabbit pAb
Supplier: ELK Biotechnology
Supplier-Nr: ES11299

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, rat, mouse
Immunogen: Synthesized peptide derived from human protein . at AA range: 1050-1130
MW: 143 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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