Anti-NR5A2

Anti-NR5A2
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Save 30% on all primary antibodies by Arigo Biolaboratories!

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*1 Offer expires 16/12/2024
Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG58707.50 50 µg - -

6 - 14 business days*

30 %
520.00€
364.00€
 
Protein function: Nuclear receptor that acts as a key metabolic sensor by regulating the... more
Product information "Anti-NR5A2"
Protein function: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha- hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. [The UniProt Consortium]
Keywords: Anti-B1F, Anti-hB1F, Anti-LRH-1, Anti-NR5A2, Anti-B1-binding factor, Anti-Liver receptor homolog 1, Anti-CYP7A promoter-binding factor, Anti-Hepatocytic transcription factor, Anti-Alpha-1-fetoprotein transcription factor
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG58707

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant protein corresponding to K44-R237 of Human NR5A2
MW: 61 kD
Format: Antigen Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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