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![Anti-NR5A2](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG44125.50 | 50 µg | - | - |
6 - 14 business days* |
520.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Nuclear receptor that acts as a key metabolic sensor by regulating the... more
Product information "Anti-NR5A2"
Protein function: Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38. {ECO:0000250, UniProtKB:P45448, ECO:0000269, PubMed:15707893, ECO:0000269, PubMed:15723037, ECO:0000269, PubMed:15897460, ECO:0000269, PubMed:16289203, ECO:0000269, PubMed:20159957}. [The UniProt Consortium]
Keywords: | Anti-B1F, Anti-hB1F, Anti-hB1F, Anti-NR5A2, Anti-LRH-1, Anti-LRH-1, Anti-B1-binding factor, Anti-B1-binding factor, Anti-Liver receptor homolog 1, Anti-Liver receptor homolog 1, Anti-CYP7A promoter-binding factor, Anti-CYP7A promoter-binding factor, Anti- |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG44125 |
Properties
Application: | FC, IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Human NR5A2 recombinant protein (Position: K192-A508) |
MW: | 61 kD |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K08027 | Matching products |
UniProt ID : | O00482 | Matching products |
Gene ID | GeneID 2494 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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