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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
N5375-17.100 | 100 µg | - | - |
3 - 19 business days* |
901.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human Notch-2 is a 300kD member of the notch family of transmembrane (TM) proteins. It is... more
Product information "Anti-Notch2 (Notch Homolog 2, Drosophila, hN2)"
Human Notch-2 is a 300kD member of the notch family of transmembrane (TM) proteins. It is synthesized as a 2446 amino acid (aa) type I TM glycoprotein that undergoes Golgi processing to generate a 180kD disulfide-linked extracellular domain (ECD) (likely aa25-1538) and a 110kD membrane bound truncated segment (likely aa1539-2471). Upon binding to Delta1, Jagged1, or Jagged2, the 110kD segment undergoes two cleavages, the second which generates an NICD (notch intracellular domain) (aa1697-2471), a potential nuclear transcription factor. In the nucleus, NICD regulates CSL pathways. When NICD is phosphorylated, it is deactivated. Applications: Suitable for use in Western Blot and ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, With an appropriate colorimetric detection system, the detection limit for rhNotch-2 ICD is ~5ng/lane under non-reducing and reducing conditions., ELISA: 0.5-1ug/ml, Detection limit for rhNotch-2 ICD is ~12ng/well., Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, PBS, and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: | United States Biological |
Supplier-Nr: | N5375-17 |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Clone: | 7H239 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | human |
Immunogen: | E.coli-derived recombinant human Notch-2 ICD segment (aa2063-2413), Accession # Q04721 |
Format: | Affinity Purified |
Database Information
KEGG ID : | K20994 | Matching products |
UniProt ID : | Q04721 | Matching products |
Gene ID : | GeneID 4853 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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