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![Anti-NF-kappaB (p65)](https://www.biomol.com/media/image/4d/bc/41/Cay20671-1_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay20671-1 | 100 µg | - |
6 - 10 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NF-kappaB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-kappaB... more
Product information "Anti-NF-kappaB (p65)"
NF-kappaB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-kappaB complex and is encoded by the RELA gene in humans. It is composed of an N-terminal Rel homology domain, which mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65. NF-kappaB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation. Genome-wide deletion of Rela in mice is embryonic lethal. Silencing of NF-kappaB p65 induces tumor cell apoptosis in a murine Lewis lung carcinoma model and decreases secreted levels of IL-1beta and TNF-alpha induced by LPS in THP-1 monocytes. NF-kappaB p65 is overexpressed in inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-kappaB p65. Cayman's NF-kappaB p65 (human, recombinant) protein can be used for Western blot and ELISA applications. Cayman's NF-kappaB (p65) Polyclonal Antibody can be used for ELISA and Western blot applications. The antibody recognizes NF-kappaB at 65 kDa from human samples.Synonyms: Nuclear Factor NF-kappaB (p65) subunit, Transcription Factor p65. Immunogen: Synthetic peptide from the C-Terminal region of human NF-kappaB (p65). Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA and WB. UniProt Accession #: Q04206.
Keywords: | Anti-RELA, Anti-NFKB3, Anti-Transcription factor p65, Anti-Transcription factor p65, Anti-Nuclear factor NF-kappa-B p65 subunit, Anti-Nuclear factor NF-kappa-B p65 subunit, Anti-Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Anti-Nu |
Supplier: | Cayman Chemical |
Supplier-Nr: | 20671 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: synthetic peptide from the C-terminal region of human p65) |
Immunogen: | Synthetic peptide from the C-Terminal region of human NF-?B (p65) |
Format: | Peptide Affinity Purified |
Database Information
KEGG ID : | K04735 | Matching products |
UniProt ID : | Q04206 | Matching products |
Gene ID | GeneID 5970 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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