Anti-NAV1.7, clone S68-6

Anti-NAV1.7 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.7 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other Nav channels. Cross-reactivity with NAV1.7 from other sources has not been determined. Channels and Transporters research. Protein function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na() ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na() channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain. [The UniProt Consortium]