Anti-Nampt (Clone OMNI 379)

Nampt is a 52 kDa adipokine secreted by adipose tissue that is involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates the insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.Synonyms: Nicotinamide Phosphoribosyltransferase, PBEF1, Pre-B Cell Colony Enhancing Factor 1, Visfatin. Immunogen: recombinant human Nampt. Clone Designation: OMNI 379. Formulation: (Request formulation change), A 1 mg/ml solution in PBS, pH 7.4. Host: Mouse. Isotype: IgG2akappa. Applications: ELISA, FC, ICC, IHC, IP, and WB. Origin: Animal/Mouse.