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![Anti-NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Re](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
N0018-64J1.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NALP3 is a cytoplasmic 115-130kD member of the NLRP family of molecules. It is selectively... more
Product information "Anti-NALP3 (NACHT-, LRR- and PYD-Containing Protein 3, AGTAVPRL, AII/AVP, Angiotensin/Vasopressin Re"
NALP3 is a cytoplasmic 115-130kD member of the NLRP family of molecules. It is selectively expressed, being found in stratified squamous and transitional epithelium, Hassell's corpuscles, neutrophils, dendritic cells and T cells. NALP3 promotes IL-1b and IL-18 maturation by activating caspase-1. It does so by forming a NALP3 inflammasome comprised of NALP3, ASC and caspase-1. Bacterial RNA and cell wall peptidoglycan can bind to NALP3, promoting (potentially) ATP binding, NALP3 oligomerization, and caspase activation. Human NALP3 is 1036aa in length. It contains an N-terminal DAPIN domain (aa1-93), a NACHT domain (aa220-536), and seven consecutive LRRs (aa740-991). Alternate splice forms are reported. Either individually, or in combination, there can be deletions of aa836-892, 721-777, and a premature truncation after Gly719 that generates a 70kD isoform. Over aa3-223, human NALP3 shares 76aa identity with mouse NALP3. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-NLRP3, Anti-CLR1.1, Anti-Caterpiller protein 1.1, Anti-PYRIN-containing APAF1-like protein 1, Anti-Cold autoinflammatory syndrome 1 protein, Anti-Angiotensin/vasopressin receptor AII/AVP-like, Anti-NACHT, LRR and PYD domains-containing protein 3 |
Supplier: | United States Biological |
Supplier-Nr: | N0018-64J1 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa4-223 from human NALP3 expressed in E. coli (Q96P20). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K12800 | Matching products |
UniProt ID : | Q96P20 | Matching products |
Gene ID | GeneID 114548 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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