Anti-NAIP

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
600-401-CX3	100 µg		-	-	6 - 10 business days*		834.00€

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Anti-NAIP Antibody was affinity purified from monospecific antiserum by immunoaffinity... more

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Product information "Anti-NAIP"

Anti-NAIP Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Minor, lower molecular weight bands may represent alternately spliced forms. Protein function: Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. [The UniProt Consortium]

Keywords:	Anti-NAIP, Anti-BIRC1, Anti-Neuronal apoptosis inhibitory protein, Anti-Baculoviral IAP repeat-containing protein 1
Supplier:	Rockland Immunochemicals
Supplier-Nr:	600-401-CX3

Properties

Application:	ELISA, IFM, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP.
Format:	Purified