Anti-Multiubiquitin Chain (Clone FK2)

Ubiquitin is a small protein composed of 76 amino acids and having a molecular weight of 8.6 kD. It exists in all eukaryotic cells and is responsible for numerous functions in the cell by post-translational modifications of substrate proteins (ubiquitination). This process is important to numerous cellular processes including, but not limited to, apoptosis, cell cycle and division, DNA transcription, immune response, modulation of cell surface receptors, and viral infections. Clone FK2 is the most widely used ubiquitin antibody. This clone reacts with mono- and polyubiquitinated conjugates, but does not react with free ubiquitin.Immunogen: Crude preparation of polyubiquitinated-lysozyme. Clone Designation: FK2. Formulation: (Request formulation change), Affinity-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 0.09% sodium azide. Host: Mouse. Isotype: IgG1kappa. Applications: ELISA, IHC, WB. Cross Reactivity: (-) Free ubiquitin.