Anti-Multiubiquitin Chain (Clone FK1)

Ubiquitin is a small protein composed of 76 amino acids and having a molecular weight of 8.6 kDa. It exists in all eukaryotic cells and is responsible for numerous functions in the cell by post-translational modifications of substrate proteins (ubiquitination). This process is important to numerous cellular processes including, but not limited to, apoptosis, cell cycle and division, DNA transcription, immune response, modulation of cell surface receptors, and viral infections. Clone FK1 reacts with polyubiquitinated conjugates, but does not react with free ubiquitin or monoubiquitinated conjugates. Cayman's Multiubiquitin Chain Monoclonal Antibody (Clone FK1) can be used for Western blotting applications in species independent samples.Immunogen: Crude preparation of polyubiquitinated-lysozyme. Clone Designation: FK1. Formulation: (Request formulation change), 100 µg of affinity-purified monoclonal antibody. Storage Buffer: 10 mM phosphate buffer, pH 7.4, with 0.15 M sodium chloride, and 0.1% sodium azide. Host: Mouse. Isotype: IgM. Applications: WB. Cross Reactivity: (+) Polyubiquitinated conjugates, (-) Free ubiquitin, (-) Monoubiquitinated conjugates.