Anti-MUC4, clone SQab20198

Anti-MUC4, clone SQab20198
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Item number Size Datasheet Manual SDS Delivery time Quantity Discount Price
ARG66765.100 100 µl - -

6 - 14 business days*

30 %
624.00€
436.80€
 
Protein function: May play a role in tumor progression. Ability to promote tumor growth may be... more
Product information "Anti-MUC4, clone SQab20198"
Protein function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell- extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site- specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. [The UniProt Consortium]
Keywords: Anti-MUC4
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG66765

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SQab20198
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant fragment within aa. 1500-2000 of Human MUC4
MW: 232 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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