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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-10-3029-P-25 | 25 tests | - |
3 - 11 business days* |
447.00€
|
|||
ABE-10-3029-P-100 | 100 tests | - |
3 - 11 business days* |
447.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously... more
Product information "Anti-mTLR9 (Clone: ABM4D70) PE conjugated"
Mouse Toll-like receptor 9 (mTLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. It has modulatory effect on the mucosal immune system, influence susceptibility to allergic sensitization to foods (22718261). TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. TLR9 signaling plays an important role in the development of robust protective immunity, proper recruitment and function of effector cells (lymphocytes and macrophages), and ultimately, effective cryptococcal clearance from the infected lungs (20581055). It is involved in the pathogenesis of cardiovascular diseases, such as hypertension and heart failure. Protein function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:18931679, PubMed:21402738, PubMed:14993594, PubMed:17474149, PubMed:25686612, PubMed:18820679). Plays a role in defense against systemic mouse cytomegalovirus infection (PubMed:14993594). Controls lymphocyte response to Helicobacter infection (PubMed:17474149). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production. [The UniProt Consortium]
Keywords: | Anti-Tlr9, Anti-CD289, Anti-Toll-like receptor 9, Monoclonal Antibody to mTLR9 (Clone: ABM4D70) PE conjugated |
Supplier: | Abeomics |
Supplier-Nr: | 10-3029-P |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | ABM4D70 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Immunogen: | A partial length recombinant mTLR9 protein (amino acids 602-860) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10161 | Matching products |
UniProt ID : | Q9EQU3 | Matching products |
Gene ID | GeneID 81897 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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