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Promotion:
Save 30% on all primary antibodies by Arigo Biolaboratories!
*1
*1 Offer expires 16/12/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ARG66198.100 | 100 µl | - | - |
6 - 14 business days* |
30 %
|
624.00€
436.80€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of the post-replicative DNA mismatch repair system (MMR).... more
Product information "Anti-MSH6, clone SQab1720"
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction. [The UniProt Consortium]
Keywords: | Anti-GTBP, Anti-p160, Anti-GTMBP, Anti-hMSH6, Anti-MutS protein homolog 6, Anti-MutS-alpha 160 kDa subunit, Anti-G/T mismatch-binding protein, Anti-DNA mismatch repair protein Msh6 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG66198 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | SQab1720 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide around the N-terminus of MSH6 |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K08737 | Matching products |
UniProt ID : | P52701 | Matching products |
Gene ID : | GeneID 2956 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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