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![Anti-Mouse PD-1 [RMP1-30] In Vivo Antibody - Low Endotoxin](https://www.biomol.com/media/image/61/ae/c6/G-IVMB0338-500_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-IVMB0338.500 | 500 µg | - | - |
9 - 20 business days* |
289.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Endotoxin level: <1.0 EU/µg as determined by the LAL method. Protein function: Inhibitory... more
Product information "Anti-Mouse PD-1 [RMP1-30] In Vivo Antibody - Low Endotoxin"
Endotoxin level: <1.0 EU/µg as determined by the LAL method. Protein function: Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:10485649, PubMed:11698646, PubMed:11209085, PubMed:21300912). Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:11015443, PubMed:11224527, PubMed:22641383, PubMed:18287011, PubMed:18641123). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:22641383). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (PubMed:11698646, PubMed:22641383). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. [The UniProt Consortium]
Keywords: | Anti-CD279, Anti-mPD-1, Anti-Protein PD-1, Anti-Programmed cell death protein 1 |
Supplier: | Assay Genie |
Supplier-Nr: | IVMB0338 |
Properties
Application: | FC, in vivo |
Antibody Type: | Monoclonal |
Clone: | RMP1-30 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Purity: | >95% (SDS Page), >95% monomer (analytical SEC) |
Format: | Functional Grade |
Database Information
KEGG ID : | K06744 | Matching products |
UniProt ID : | Q02242 | Matching products |
Gene ID | GeneID 18566 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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