Anti-Mouse IL-10 (APC Conjugated)[JES5-16E3], clone JES5-16E3

Anti-Mouse IL-10 (APC Conjugated)[JES5-16E3], clone JES5-16E3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-F1197UE.25 25 µg -

7 - 16 business days*

85.00€
E-AB-F1197UE.100 100 µg -

7 - 16 business days*

226.00€
 
L-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its... more
Product information "Anti-Mouse IL-10 (APC Conjugated)[JES5-16E3], clone JES5-16E3"
L-10 was originally described as Cytokine Synthesis Inhibitory Factor (CSIF) by virtue of its ability to inhibit cytokine production by Th1 clones. IL-10 shares over 80% sequence homology with the Epstein-Barr virus protein BCRFI. IL-10 inhibits IFN-gamma, TNF-beta, and IL-2 production by Th1 clones, inhibits macrophage-mediated IL-1, IL-6, and TNF-alpha synthesis, suppresses the delayed type hypersensitivity response, stimulates Th2 cell response (which results in elevated antibody production), and promotes mast cell proliferation in combination with IL-4. Protein function: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (PubMed:28473584). [The UniProt Consortium]
Keywords: Anti-CSIF, Anti-Il10, Anti-IL-10, Anti-Il-10, Anti-Interleukin-10, Anti-Cytokine synthesis inhibitory factor, Anti-Mouse IL-10 Monoclonal Antibody(APC Conjugated)[JES5-16E3]
Supplier: Elabscience
Supplier-Nr: E-AB-F1197UE

Properties

Application: ICFC
Antibody Type: Monoclonal
Clone: JES5-16E3
Conjugate: APC
Host: Rat
Species reactivity: mouse

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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