Anti-Mouse FcepsilonRIalpha (APC Conjugated)[MAR-1], clone MAR-1

FcepsilonRIalpha is a transmembrane protein belonging to the Ig superfamily. FcepsilonRIalpha forms a tetrameric complex with one beta and two gamma-subunits. The FcepsilonRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcepsilonRIalpha, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcepsilonRIalpha subunit. Protein function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. [The UniProt Consortium]