Anti-MLKL, clone 8H7

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-22249.20 20 µl -

7 - 16 business days*

72.00€
E-AB-22249.60 60 µl -

7 - 16 business days*

142.00€
E-AB-22249.120 120 µl -

7 - 16 business days*

238.00€
E-AB-22249.200 200 µl -

7 - 16 business days*

395.00€
 
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein... more
Product information "Anti-MLKL, clone 8H7"
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. Protein function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). [The UniProt Consortium]
Keywords: Anti-hMLKL, Anti-Mixed lineage kinase domain-like protein, MLKL Monoclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-22249

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: 8H7
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Synthetic Peptide of MLKL
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-MLKL, clone 8H7"
Write a review
or to review a product.
-30 %
Discount Promotion
Anti-MLKL Anti-MLKL
624.00€ * 436.80€ *
Viewed