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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES10756.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES10756.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act... more
Product information "Anti-MIB2"
function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification, protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,similarity:Contains 1 ZZ-type zinc finger.,similarity:Contains 2 MIB/HERC2 domains.,similarity:Contains 2 RING-type zinc fingers.,similarity:Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney., Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Cytoplasm . Endosome . Colocalizes with endosomal compartments.
Keywords: | Anti-SKD, Anti-Novelzin, EC=2.3.2.27, Anti-Skeletrophin, Anti-Mind bomb homolog 2, Anti-Novel zinc finger protein, Anti-E3 ubiquitin-protein ligase MIB2, Anti-RING-type E3 ubiquitin transferase MIB2, Anti-Putative NF-kappa-B-activating protein 002N, MIB2 |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES10756 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthesized peptide derived from part region of human protein |
MW: | 111 kD |
Format: | Purified |
Database Information
KEGG ID : | K10645 | Matching products |
UniProt ID : | Q96AX9 | Matching products |
Gene ID : | GeneID 142678 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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