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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F47999-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F47999-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. MIB is an E3 ubiquitin-protein ligase that mediates... more
Product information "Anti-Mib1"
In 1X PBS, pH 7.4, with 0.09% sodium azide. MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. [The UniProt Consortium]
Keywords: | Anti-DIP1, Anti-MIB1, Anti-DIP-1, EC=6.3.2.-, Anti-Mind bomb homolog 1, Anti-DAPK-interacting protein 1, Anti-E3 ubiquitin-protein ligase MIB1, Anti-Zinc finger ZZ type with ankyrin repeat domain protein 2, Mib1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F47999 |
Properties
Application: | IF, IHC, WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A portion of amino acids 13-42 from the human protein was used as the immunogen for this Mib1 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K10645 | Matching products |
UniProt ID : | Q86YT6 | Matching products |
Gene ID : | GeneID 57534 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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