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![Anti-MIB1 (E3 Ubiquitin-protein Ligase MIB1, Mind Bomb Homolog 1, DAPK-interacting Protein 1, DIP-1,](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
M3753-01C.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MIB1 (Mind bomb 1? also DIP1 and ZZANK2) is a 110-115kD E3 ubiquitin ligase. It is widely... more
Product information "Anti-MIB1 (E3 Ubiquitin-protein Ligase MIB1, Mind Bomb Homolog 1, DAPK-interacting Protein 1, DIP-1,"
MIB1 (Mind bomb 1? also DIP1 and ZZANK2) is a 110-115kD E3 ubiquitin ligase. It is widely expressed in both embryo and adult, and appears to have a non redundant role in Notch receptor signaling. Notch signaling is initiated when a transmembrane (TM) Notch ligand (Jagged or Delta) binds to Notch on an adjacent cell. This ligation induces cleavage of the Notch extracellular domain (ECD) with the creation of a Jagged/Delta:NotchECD complex. This complex is now internalized by the Notch ligand expressing cell. The displacement of the NotchECD from its TM segment promotes further Notch processing, resulting in Notch signaling. The key internalization step by the ligand expressing cell is mediated by the MIB1 E3 ubiquitin ligase. Human MIB1 is 1006aa in length. It contains multiple interspersed Ankyrin repeats, MIB domains, and zinc finger motifs. There is one potential alternative start site at Met84. Over aa365-461, human MIB1 shares 99% aa sequence identity with mouse MIB1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-DIP1, Anti-MIB1, Anti-DIP-1, EC=6.3.2.-, Anti-Mind bomb homolog 1, Anti-DAPK-interacting protein 1, Anti-E3 ubiquitin-protein ligase MIB1, Anti-Zinc finger ZZ type with ankyrin repeat domain protein 2 |
Supplier: | United States Biological |
Supplier-Nr: | M3753-01C |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant corresponding to aa365-461 from human MIB1 expressed in E.coli. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K10645 | Matching products |
UniProt ID : | Q86YT6 | Matching products |
Gene ID | GeneID 57534 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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