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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon... more
Product information "Anti-MAVS"
This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. [The UniProt Consortium]
Keywords: | Anti-IPS1, Anti-VISA, Anti-MAVS, Anti-IPS-1, Anti-Cardif, Anti-Virus-induced-signaling adapter, Anti-CARD adapter inducing interferon beta, Anti-Mitochondrial antiviral-signaling protein, Anti-Putative NF-kappa-B-activating protein 031N, MAVS Polyclonal A |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-61105 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein of human MAVS |
Database Information
KEGG ID : | K12648 | Matching products |
UniProt ID : | Q7Z434 | Matching products |
Gene ID : | GeneID 57506 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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