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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
M2867-56R.50 | 50 µg | - | - |
3 - 19 business days* |
765.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MEKK7, known as TAK1 for transforming growth factor (TGF) beta-activated kinase-1, is a MLK... more
Product information "Anti-MAP3K7, ID (Mitogen-activated Protein Kinase Kinase Kinase 7, Transforming Growth Factor-beta-a"
MEKK7, known as TAK1 for transforming growth factor (TGF) beta-activated kinase-1, is a MLK (MAP3K) type protein kinase which is associated with several signaling pathways. The protein contains a N-terminal protein kinase domain preceeded by a short regulatory motif and followed by a C-terminal extension of unknown function. TAK1 is activated by TGF beta and tumor necrosis factor (TNF). Further, TAK1 binding proteins, TAB-1 and -2, bind to the N-terminal regulatory motif and couple TAK1 to additional upstream signals, including the human X chromosome-linked inhibitor of apoptosis. TAK1 regulates the JNK cascade by phosphorylating MKK4/MAP2K4 and p38 cascades by phosphorylating MEK3/MAP2K3 and MKK6/MAP2K6. TAK1 also has been implicated in interleukin-1 (IL-1) signaling to JNKs via direct activation by IL-1 or by forming a complex with TRAF6, TAB1 and TAB2. At least four protein isoforms, resulting from alternatively spliced transcript variants, have been identified - 491, 518, 579 and 606aa. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:40,000, Western Blot: 1:500-1:1000, Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=2.7.11.25, Anti-TGF-beta-activated kinase 1, Anti-Mitogen-activated protein kinase kinase kinase 7, Anti-Transforming growth factor-beta-activated kinase 1 |
Supplier: | United States Biological |
Supplier-Nr: | M2867-56R |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to human MAP3K7. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04427 | Matching products |
UniProt ID : | O43318 | Matching products |
Gene ID | GeneID 6885 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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