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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
M2352-10E.100 | 100 µg | - | - |
3 - 19 business days* |
537.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and... more
Product information "Anti-MAP Kinase p44/42 (MAPK1/MAPK3, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1,"
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotidebinding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase(ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Immunogen: Synthetic peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:5000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=2.7.11.24, Anti-MAP kinase 1, Anti-MAP kinase 2, Anti-MAP kinase isoform p42, Anti-Mitogen-activated protein kinase 2, Anti-Mitogen-activated protein kinase 1, Anti-Extracellular signal-regulated kinase 2 |
Supplier: | United States Biological |
Supplier-Nr: | M2352-10E |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 12E12 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
Immunogen: | Human MAP Kinase p44/42 |
Format: | Purified |
Database Information
KEGG ID : | K04371 | Matching products |
UniProt ID : | P28482 | Matching products |
Gene ID : | GeneID 5594 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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