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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V2695-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V2695-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 42-46kDa,... more
Product information "Anti-MAGE-1, clone MZ2E/838"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 42-46kDa, identified as MAGE-1. This mAb does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy. Protein function: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. [The UniProt Consortium]
Keywords: | Anti-CT1.1, Anti-MAGE1, Anti-MAGEA1, Anti-Antigen MZ2-E, Anti-MAGE-1 antigen, Anti-Cancer/testis antigen 1.1, Anti-Melanoma-associated antigen 1, MAGE-1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V2695 |
Properties
Application: | FC, IF, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | MZ2E/838 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human MAGEA1 protein |
Format: | Purified |
Database Information
KEGG ID : | K24127 | Matching products |
UniProt ID : | P43355 | Matching products |
Gene ID : | GeneID 4100 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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