Anti-Lck (Clone: ABM18H9)

Anti-Lck (Clone: ABM18H9)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-10-8003-25 25 µg -

3 - 11 business days*

149.00€
ABE-10-8003-100 100 µg -

3 - 11 business days*

418.00€
 
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the... more
Product information "Anti-Lck (Clone: ABM18H9)"
Protein function: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). [The UniProt Consortium]
Keywords: Anti-LCK, Anti-LSK, Anti-p56-LCK, EC=2.7.10.2, Anti-Protein YT16, Anti-Proto-oncogene Lck, Anti-Tyrosine-protein kinase Lck, Anti-Leukocyte C-terminal Src kinase, Anti-T cell-specific protein-tyrosine kinase, Monoclonal Antibody to Lck (Clone: ABM18H9)
Supplier: Abeomics
Supplier-Nr: 10-8003

Properties

Application: WB
Antibody Type: Monoclonal
Clone: ABM18H9
Conjugate: No
Host: Mouse
Species reactivity: human
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-Lck (Clone: ABM18H9)"
Write a review
or to review a product.
Viewed