Anti-KSR2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA035536.25	25 µl		-		7 - 10 business days*		239.00€
ATA-HPA035536.100	100 µl		-		7 - 10 business days*		477.00€

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Protein function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase... more

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Product information "Anti-KSR2"

Protein function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF, upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 (PubMed:29433126). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF- kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 95% and to rat: 96%

Keywords:	Anti-KSR2, Anti-hKSR2, Anti-Kinase suppressor of Ras 2
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA035536

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LPASHYYKYK QQFIFPDVVP VPETPTRAPQ VILHPVTSNP ILEGNPLLQI EVEPTSENEE VHDEAEESED DFEEMNLSLL S (ATA-APrEST80470)