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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00718-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00718 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin... more
Product information "Anti-JMY (IHC)"
Protein function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. [The UniProt Consortium]
Keywords: | Anti-JMY, Anti-Junction-mediating and -regulatory protein |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00718 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse, bovine, dog, guinea pig, panda, rhesus monkey, gorilla, chimpanzee, small-eared galago, little brown bat, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00718 maps to a region between residue 1 and 50 of human junction mediating and regulatory protein using the numbering given in entry NP_689618.3 (GeneID 133746). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K24045 | Matching products |
UniProt ID : | Q8N9B5 | Matching products |
Gene ID : | GeneID 133746 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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