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![Anti-JMJD3 (KDM6B)](https://www.biomol.com/media/image/25/7c/18/NSJ-F40552-0-08ML_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F40552-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F40552-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. Covalent modification of histones plays critical role... more
Product information "Anti-JMJD3 (KDM6B)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. Protein function: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. [The UniProt Consortium]
Keywords: | Anti-Jmjd3, Anti-Kdm6b, EC=1.14.11.-, Anti-Lysine-specific demethylase 6B, Anti-JmjC domain-containing protein 3, Anti-Jumonji domain-containing protein 3, JMJD3 Antibody (KDM6B) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F40552 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | A portion of amino acids 954-987 from the mouse protein was used as the immunogen for this JMJD3 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K11448 | Matching products |
UniProt ID : | Q5NCY0 | Matching products |
Gene ID | GeneID 216850 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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