Anti-JARID1B/PLU1 (C-Term)

Jumonji AT rich interactive domain 1B (JARID1B) nuclear proteins are potential histone demethylases. JARID1B demethylation of Lys-4 of histone H3 plays an important role in breast cancer cell proliferation through BRCA1 repression. JARID1B acts as a transcriptional co-repressor of two developmental transcription factors, PAX-9 and BF1, which are crucial for organogenesis in mouse embryo. JARID1B has also been shown to interact directly with histone deacetylase.Synonyms: CT31, Jumonji/ARID domain-containing protein 1B, KDM5B, Lysine-specific Demethylase 5B, RBBP2H1. Immunogen: Synthetic peptide from the C-terminal region of human JARID1B/PLU1. Formulation: (Request formulation change), Peptide affinity-purified polyclonal antibody. Storage Buffer: TBS, pH 7.4 with 50% glycerol, 0.1% BSA and 0.02% sodium azide. Host: Rabbit. Applications: FC and ICC. UniProt Accession #: Q9UGL1.