Anti-JARID1B (IHC)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IHC-00370-T	10 µl (2500 ng)		-		2 - 8 business days*		164.00€
IHC-00370	100 µl (25 µg)		-		2 - 8 business days*		623.00€

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Protein function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a... more

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Product information "Anti-JARID1B (IHC)"

Protein function: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. [The UniProt Consortium]

Keywords:	Anti-CT31, Anti-PLU-1, Anti-KDM5B, Anti-JARID1B, Anti-RBP2-H1, EC=1.14.11.-, Anti-Cancer/testis antigen 31, Anti-Histone demethylase JARID1B, Anti-Lysine-specific demethylase 5B, Anti-Jumonji/ARID domain-containing protein 1B
Supplier:	Bethyl Laboratories
Supplier-Nr:	IHC-00370

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: dog, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, african elephant, small-eared galago, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by IHC-00370 maps to a region between residue 1494 and 1544 of human Jumonji, AT rich interactive domain 1B using the numbering given in entry NP_006609.3 (GeneID 10765).
Format:	Antigen Affinity Purified