Anti-JARID1A/RBP2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-897A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A300-897A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3,... more

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Product information "Anti-JARID1A/RBP2"

Protein function: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1. [The UniProt Consortium]

Keywords:	Anti-KDM5A, Anti-RBBP-2, Anti-JARID1A, EC=1.14.11.-, Anti-Histone demethylase JARID1A, Anti-Lysine-specific demethylase 5A, Anti-Retinoblastoma-binding protein 2, Anti-Jumonji/ARID domain-containing protein 1A
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-897A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat, dog, horse, rabbit, guinea pig, panda, orangutan, gorilla, chinese hamster, small-eared galago, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-897A-T maps to a region between residue 1640 and 1690 of human Jumonji/ARID Domain-Containing Protein 1A/Retinoblastoma Binding Protein 2 Homolog 1 using the numbering given in entry NP_001036068.1 (GeneID 5927).
Format:	Antigen Affinity Purified