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![Anti-IRF3](https://www.biomol.com/media/image/2c/6d/ee/Cay24937-100_600x600.png)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24937-100 | 100 µg | - |
6 - 10 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Interferon regulatory factor 3 (IRF3) is a member of the IRF family that plays a crucial role in... more
Product information "Anti-IRF3"
Interferon regulatory factor 3 (IRF3) is a member of the IRF family that plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity. Double-stranded RNA generated during a viral infection leads to IRF3 activation through serine/threonine phosphorylation by TBK1 (Cay-22817) or IKKepsilon (IKBKE) kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREB binding protein (CREBBP)/p300. The complex formed by this association, known as DRAF1, activates transcription of interferon alpha (IFN-alpha) and IFN-beta as well as other IFN-induced genes, which play a critical role in the type 1 IFN-dependent immune response. Cayman's IRF3 Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes IRF3 at ~47 kDa from human samples.Synonyms: Interferon Regulatory Factor 3. Immunogen: Human recombinant IRF3. MW: 47 kDa. Formulation: (Request formulation change), 100 µg of protein A-purified IgG. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, IHC, and WB. UniProt Accession #: Q14653.
Keywords: | Anti-IRF-3 {ECO:0000303|PubMed:9566918}, Anti-IRF-3 {ECO:0000303|PubMed:9566918}, Anti-Interferon regulatory factor 3 {ECO:0000303|PubMed:9566918, ECO:0000303|PubMed:9803267}, Anti-Interferon regulatory factor 3 {ECO:0000303|PubMed:9566918, ECO:0000303|Pu |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24937 |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Human recombinant IRF3 |
Format: | Purified |
Database Information
KEGG ID : | K05411 | Matching products |
UniProt ID : | Q14653 | Matching products |
Gene ID | GeneID 3661 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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