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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recognizes mouse IL-33. Liquid. Purified from HEK 293 cell culture supernatant. Interleukin-33... more
Product information "Anti-Interleukin-33 (mouse) (rec.) (blocking), clone Bondy-1-1 (preservative free)"
Recognizes mouse IL-33. Liquid. Purified from HEK 293 cell culture supernatant. Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. anti-IL-33, mAb (recombinant) (blocking) (Bondy-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
Keywords: | Anti-IL33, Anti-IL-33 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-27B-0013PF |
Properties
Application: | ELISA, FA |
Antibody Type: | Monoclonal |
Clone: | Bondy-1-1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | mouse |
Immunogen: | Mouse recombinant IL-33. |
Format: | Purified |
Database Information
KEGG ID : | K12967 | Matching products |
UniProt ID : | Q8BVZ5 | Matching products |
Gene ID : | GeneID 77125 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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